Simpson was on the old Beef Road, the trail over which the Texas cattlemen drove their herds of wild long-horned cattle to shipping points on the Red River.

Among the first settlers in the area were the Simpsons, for whom the town was named, and a Dr. Mims.  The first settler was Elias Hayman, who settled with his family just two or three miles from the center of the community of Simpson.

--Leeper, Clare D'Artois. Louisiana Place Names: Popular, Unusual, and Forgotten Stories of Towns, Cities, Plantations, Bayous, and Even Some Cemeteries. Louisiana State University Press.